A different approach, bypassing the Check Point Inhibitor.
What is the role of T-cells in the immune system?
T Cells are the immune systems soldiers who search out and destroy the foreign invaders, such as flu and cancer.
Chimeric antigen receptor CAR T Cell
- CAR T Cell Therapy is a way of engineering the bodies T Cells to recognise cancer, by reprogramming the bodies own T Cells to recognise and destroy the cancer.
- T Cells are removed from the patient and then the patients Tumour antigens are added to teach the T Cells.
- The newly modified T Cells are then grown into the millions and then reintroduced into the patients body.
- CAR T-cell therapy, is a new form of immunotherapy that uses specially altered T cells to directly and precisely target cancer cells.
The immune system is made up of a variety of cells and organs that normally protect the body from infection and cancer. An important component of the immune system are T cells, which have the capacity to hunt down and destroy abnormal cells, including some cancer cells.
Sometimes, cancer cells find ways to evade the immune system; so, the immune system needs to be retrained and enhanced to recognize and attack cancer cells. CAR T-cell therapy is one innovative approach to program and strengthen the immune system to attack some forms of cancer.
After a small portion of a patient’s own T cells has been collected from the blood, these cells are re-engineered in a special laboratory so they now carry special structures called chimeric antigen receptors (CARs) on their surface.
When these CAR T cells are reinjected into the patient, they multiply rapidly and these engineered receptors may help the T cells to identify and attack cancer cells throughout the body.
CAR T-cell therapy has been shown to be effective in B-cell acute lymphoblastic leukaemia (ALL) and adult diffuse large B-cell lymphoma (DLBCL).
There are no approved CAR-T treatments worldwide for solid cancers. However, research is underway at Peter Mac in CAR-T cell treatment of solid cancers. Please see Clinical Trials.gov for further information.
Page Source https://www.petermac.org/car-t