A cancer originating within the Bile Ducts
Cholangiocarcinoma Abbreviations: CC 0r CCA
Cholangiocarcinoma originates in the thin Bile Duct tube which is about 125 -150 mm long, extending from the liver to the small intestine (Duodenum). The bile ducts function is to move a fluid called bile from the liver and gallbladder to the small intestine, where it helps digest the fats in food.
Different parts of the bile duct system have different names. In the liver it begins as many tiny tubes (ductules) where bile collects from the liver cells. The ductules come together to form small ducts, which then merge into larger ducts and eventually the left and right hepatic ducts. The ducts within the liver are called Intrahepatic bile ducts. These are the ducts that exit from the liver and join together and form the common hepatic duct at the hilum.
About one-third of the way along the length of the bile duct, the gallbladder (an organ that stores bile) attaches by a small duct called the cystic duct. The combined duct is called the common bile duct. The common bile duct passes through part of the pancreas before it empties into the first part of the small intestine (the duodenum), next to where the pancreatic duct also enters the small Duodenum.
Tumours can develop in any part of the bile duct and, based on their location, are classified into 3 types. (Primary)
Cancers in these different areas may cause different symptoms.
Cholangiocarcinoma can also be divided into types based on how the cancer cells look under the microscope. More than 95% of bile duct cancers are carcinomas and most are adenocarcinomas. Adenocarcinomas are cancers of glandular cells that can develop in several organs of the body. Bile duct adenocarcinomas develop from the mucous glands that line the inside of the duct. Cholangiocarcinoma is another name for a bile duct carcinoma.
Content reinterpreted from CCF
The Cholangiocarcinoma Foundation
Adenocarcinomas are also prominent in
- Lung cancer: Non-small cell lung cancer accounts for 80 percent of lung cancers, and adenocarcinoma is the most common type.
- Prostate cancer: Cancer that forms in the prostate gland is typically an adenocarcinoma, which accounts for 99 percent of all prostate cancers.
- Pancreatic cancer: Exocrine pancreatic cancer tumors are called adenocarcinomas. They form in the pancreas ducts.
- Esophageal cancer: Cancer that forms in the glandular cells of the esophagus is known as adenocarcinoma. This is the most common type of esophageal cancer.
- Colorectal cancer: Cancer that develops in the intestinal gland cells that line the inside of the colon and/or rectum is an adenocarcinoma. It makes up 95 percent of colon and rectal cancers.
- Adenocarcinoma may also develop elsewhere in the body.